Like you, I used to run studies. And in the days before EDC it could be really painful.
When I was a Study Manager and a Data Manager for a large medical device company, we used carbon-based CRFs. We’d manage discrepancies by communicating through fax. Randomizations would be through a batch of envelopes sent to the sites. Inevitably, they’d open the wrong envelope, get the wrong randomization assignment, and you’d scramble to correct things. It was a mess, but that’s how things were run back in the day.
The industry has definitely evolved from those days. We eventually started using EDC systems, but they always underwhelmed me.
Then I saw eClinicalOS (eCOS) and I fell in love. I knew right away that the system would make my life easier in so many ways.